High Rate of Inappropriate Antibiotics in Patients with Hematologic Malignancies and Pseudomonas aeruginosa Bacteremia following International Guideline Recommendations
Mariana Chumbita, Pedro Puerta‐Alcalde, Lucrecia Yáñez, María Ángeles Cuesta, Anabelle Chinea, Ignacio Español, Pascual Fernández, Carlota Gudiol, Pedro Antonio González Sierra, Rafael Rojas, José María Sánchez‐Pina, Irene Sánchez Vadillo, Miguel A. Sánchez, Rosario Varela, Lourdes Vázquez, Manuel Guerreiro, Patricia Monzó, Carlos Lopera, Tommaso Francesco Aiello, Olivier Peyrony, Àlex Soriano, Carolina García‐Vidal
Abstract
Bloodstream infection (BSI) caused by P. aeruginosa is related with an elevated morbidity and mortality in neutropenic patients. For this reason, optimal antipseudomonal coverage has been the basis of all historical recommendations in the empirical treatment of febrile neutropenia. However, in recent years the emergence of multiple types of antibiotic resistances has posed a challenge in treating infections caused by this microorganism. In our study we postulated that P. aeruginosa-causing BSI in patients with hematologic malignancies is commonly resistant to antibiotics recommended in international guidelines. This observation is associated with frequent IEAT and increased mortality. Consequently, there is a need for a new therapeutic strategy.