Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer’s disease: role of the P2Y2 receptor and endoplasmic reticulum stress
Junyoung Hong, Soon‐Gook Hong, Jonghae Lee, Joon‐Young Park, Jason L. Eriksen, Bridgette V. Rooney, Yoonjung Park
Abstract
A limited study has investigated whether exercise training can improve cerebrovascular function in Alzheimer's disease. The novel findings of the study are that exercise training improves cerebrovascular dysfunction through enhancing P2Y2 receptor-mediated eNOS signaling and reducing ER stress-associated pathways in AD. These data suggest that exercise training, which regulates P2Y2 receptor and ER stress in AD brain, is a potential therapeutic strategy for Alzheimer's disease.
Topics & Concepts
Endoplasmic reticulumEnosUnfolded protein responseDiseaseReceptorMedicineAlzheimer's diseaseInternal medicineEndocrinologyNeurosciencePsychologyCell biologyBiologyNitric oxideNitric oxide synthaseAdenosine and Purinergic SignalingTryptophan and brain disordersEndoplasmic Reticulum Stress and Disease