Dynamic Solid-State Ultrasound Contrast Agent for Monitoring pH Fluctuations <i>In Vivo</i>
Julia Ann-Therese Walker, Xiaowei Wang, Karlheinz Peter, Kristian Kempe, Simon R. Corrie
Abstract
layer. This demonstrates that reduction in pH below healthy physiological levels resulted in significant increases in ultrasound contrast, in gel phantoms, mouse cadaver tissue, and live mice. The future of such materials could be developed into a platform of biomarker-responsive ultrasound contrast agents for clinical applications.
Topics & Concepts
MicrobubblesUltrasoundMaterials scienceBiomedical engineeringMagnetic resonance imagingBiosensorNanotechnologyRadiologyMedicinePhotoacoustic and Ultrasonic ImagingUltrasound and Hyperthermia ApplicationsUltrasound Imaging and Elastography