Diosmetin alleviates benzo[<i>a</i>]pyrene-exacerbated H1N1 influenza virus-induced acute lung injury and dysregulation of inflammation through modulation of the PPAR-γ-NF-κB/P38 MAPK signaling axis
Beixian Zhou, Linxin Wang, Sushan Yang, Yueyun Liang, Yuehan Zhang, Xiping Pan, Jing Li
Abstract
Diosmetin suppressed the enhanced pro-inflammatory response and apoptosis via inhibition of the augmentation of NF-κB and P38 kinase activation in a PPAR-γ-dependent manner, facilitating the alleviation of B[ a ]P-exacerbated H1N1 virus-induced respiratory illness.
Topics & Concepts
p38 mitogen-activated protein kinasesInflammationNF-κBInfluenza A virusMAPK/ERK pathwaySignal transductionApoptosisPeroxisome proliferator-activated receptorLungVirusChemistryMedicineCell biologyImmunologyBiologyReceptorInternal medicineBiochemistryPeroxisome Proliferator-Activated ReceptorsImmune Response and InflammationNF-κB Signaling Pathways