Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China
Mingli Yuan, Wen Yin, Zhaowu Tao, Weijun Tan, Yi Hu
Abstract
We retrospective studied 27 consecutive patients who were confirmed 2019 novel coronavirus (2019-nCoV) infected pneumonia. 27 patients included 12 men and 17 women, with median age of 60 years (IQR 47-69). 17 patients discharged in recovered condition and 10 patients died in hospital. The median age of mortality group was higher compared to survival group (68 (IQR 63-73) vs 55 (IQR 35-60), P = 0.003). The comorbidity rate in mortality group was significantly higher than in survival group (80% vs 29%, P = 0.018), especially comorbid hypertension, diabetes, and cardiac disease. The predominant CT characteristics consisted of ground glass opacity (67%), bilateral sides involved (86%), both peripheral and central distribution (74%), and lower zone involvement (96%). A simple CT scoring method described before (Feng F, et al PloS one. 2014;9:e93885) was used. The median CT score of mortality group was higher compared to survival group (30 (IQR 7-13) vs 12 (IQR 11-43), P = 0.021), with more frequency of consolidation (40% vs 6%, P = 0.047) and air bronchogram (60% vs 12%, P = 0.025). Comparison of CT images between survival group (A-C) and mortality group (D-F) was shown in Fig1. In the receiver operating characteristic curve analysis, an optimal cutoff value of a CT score of 24.5 had a sensitivity of 85.6% and a specificity of 84.5% for the prediction of mortality. <fig><object-id>erj;56/suppl_64/2392/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>