Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient
Pedro Rifes, Marc Isaksson, Gaurav Rathore, Patrick Aldrin-Kirk, Oliver Knights Møller, Guido Barzaghi, Julie Lee, Kristoffer L. Egerod, Dylan M. Rausch, Malin Parmar, Tune H. Pers, Thomas Laurell, Agnete Kirkeby
Topics & Concepts
Neural tubeBiologyCell biologyEmbryonic stem cellWnt signaling pathwayForebrainNeural developmentNeural stem cellNeural plateInduced pluripotent stem cellNeuroepithelial cellDirected differentiationOrganogenesisStem cellEmbryoid bodyNeurosphereTranscriptomeNeural cellAnatomyAdult stem cellNeuroscienceEmbryoCellGene expressionGeneGeneticsSignal transductionCentral nervous systemSingle-cell and spatial transcriptomicsPluripotent Stem Cells Research3D Printing in Biomedical Research