11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling
Hanwen Li, Sihan Hu, Runze Wu, Hongyou Zhou, Kai Zhang, Ke Li, Wenzheng Lin, Qin Shi, Hao Chen, Shan Lv
Abstract
) growth through reduction of PDFG-BB secretion. Finally, transcriptome sequencing of 11β-HSD1 knock in osteoclast progenitor cells indicated the Hippo pathway1 was mostly enriched. Then, by suppression of YAP expression in Hippo signaling, we observed the redundant of osteoclasts formation even in 11β-HSD1 high expression conditions. In conclusion, our study demonstrated the role of 11β-HSD1 in facilitating osteoclasts formation and maturation through the Hippo signaling, which is a new therapeutic target to manage osteoporosis.
Topics & Concepts
Osteoclast11β-hydroxysteroid dehydrogenase type 1EndocrinologyInternal medicineOvariectomized ratOsteoporosisCathepsin KBone remodelingCell biologyChemistryHippo signaling pathwaySignal transductionOsteoblastCortisoneRANKLBiologyDehydrogenaseEnzymeIn vitroHormoneMedicineReceptorActivator (genetics)BiochemistryHormonal Regulation and HypertensionEstrogen and related hormone effectsSexual Differentiation and Disorders