New cyclometalated Ru(<scp>ii</scp>) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes
Jakub Červinka, Alba Hernández-García, Delia Bautista, Lenka Marková, Hana Kostrhunová, Jaroslav Malina, Jana Kašpárková, M. Dolores Santana, Viktor Brabec, José Ruiz
Abstract
A new generation of benzimidazole-based cyclometalated ruthenium( ii ) complexes with bpy or dpq as ancillary ligands are effective against hypoxic cancers via green light activation and can directly disrupt phospholipid membranes and trigger oncosis.
Topics & Concepts
MembraneChemistryCancerCancer cellCell biologyBiophysicsBiologyBiochemistryGeneticsMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications