A novel facile one-pot synthesis of photothermally responsive carbon polymer dots as promising drug nanocarriers
Grazia M. L. Consoli, Maria Laura Giuffrida, Cristina Satriano, Teresa Musumeci, Giuseppe Forte, Salvatore Petralia
Abstract
-isopropylacrylamide), were synthetized by a novel, simple, solvent- and reagent-free method. The formation of CPDs-PNM was controlled by both temperature and heating time. The CPDs-PNM exhibited LCST behaviour, high photothermal conversion efficiency, curcumin loading capacity and no toxicity to eukaryotic cells. Proof of concept experiments confirmed an excellent thermally induced drug release activity to be used for photothermally controlled drug release.
Topics & Concepts
NanocarriersLower critical solution temperaturePhotothermal therapyPolymerMaterials scienceReagentCarbonizationPhotothermal effectNanotechnologySolventChemistryChemical engineeringDrug deliveryOrganic chemistryAdsorptionComposite materialCopolymerEngineeringCarbon and Quantum Dots ApplicationsGold and Silver Nanoparticles Synthesis and ApplicationsQuantum Dots Synthesis And Properties