Dually regulating the proliferation and the immune microenvironment of melanoma<i>via</i>nanoparticle-delivered siRNA targeting onco-immunologic CD155
Yan Wang, Ying‐Li Luo, Yifang Chen, Zi-Dong Lu, Yue Wang, Anna Czarna, Song Shen, Cong‐Fei Xu, Jun Wang
Abstract
significantly inhibited the growth of B16-F10 melanoma. Our study suggests that nanoparticle-delivered siCD155 may be a simple but effective strategy for inhibiting tumor proliferation and reprogramming TIME.
Topics & Concepts
Immune systemMelanomaCancer researchTumor microenvironmentChemistryCell biologyImmunologyBiologyRNA Interference and Gene DeliveryImmunotherapy and Immune ResponsesNanoplatforms for cancer theranostics