Roles of Androgen Receptor Signaling in Urothelial Carcinoma
Debasish Sundi, Katharine A. Collier, Yuanquan Yang, Dayssy A. Diaz, Kamal S. Pohar, Eric A. Singer, Sanjay Gupta, William E. Carson, Steven K. Clinton, Zihai Li, Edward M. Messing
Abstract
Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.
Topics & Concepts
Androgen receptorCarcinogenesisCancer researchAndrogenMedicineBladder cancerDiseaseReceptorOncologyCancerBioinformaticsInternal medicineBiologyHormoneProstate cancerBladder and Urothelial Cancer TreatmentsUrinary and Genital Oncology StudiesCancer Immunotherapy and Biomarkers