Exercise Is Muscle Mitochondrial Medicine
Ashley N. Oliveira, Brandon J. Richards, Mikhaela Slavin, David A. Hood
Abstract
Exercise stimulates the biogenesis of mitochondria in muscle. Some literature supports the use of pharmaceuticals to enhance mitochondria as a substitute for exercise. We provide evidence that exercise rejuvenates mitochondrial function, thereby augmenting muscle health with age, in disease, and in the absence of cellular regulators. This illustrates the power of exercise to act as mitochondrial medicine in muscle.
Topics & Concepts
Mitochondrial biogenesisMitochondrionMedicineMitochondrial myopathyExercise physiologyMitochondrial DNAPhysical exerciseEndurance trainingSkeletal muscleBioinformaticsPhysiologyMEDLINEBiologySports medicineMyocyteCell biologyEndocrinologyMitochondrial diseaseInternal medicineBiogenesisPharmacologyAdipose Tissue and MetabolismMitochondrial Function and PathologyCardiovascular and exercise physiology