A novel PARP-ATR dual inhibitor exhibits anti-triple-negative breast cancer activity by inducing excessive DNA damage in the mitotic phase
Chenchen Wang, Ji‐Long Duan, Nian‐Dong Mao, Miao He, Pengpeng Zhang, Yinghui Yuan, Yuan Gao, Xingrui He, Xinyi Shao, Siye Wang, Zi Hui, Hang Zhang, Ben C.B. Ko, Xiang‐Yang Ye
Topics & Concepts
PARP inhibitorDNA damagePoly ADP ribose polymeraseMitosisBreast cancerDNACancer researchBiologyTriple-negative breast cancerMolecular biologyCancerChemistryGeneticsCell biologyPolymeraseDNA Repair MechanismsPARP inhibition in cancer therapyCRISPR and Genetic Engineering