Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast
Deze Kong, Sijin Li, Christina D. Smolke
Abstract
Our work demonstrates yeast as a platform for characterizing putative plant gene clusters with the potential for compound structure and enzymatic activity discovery.
Topics & Concepts
Chalcone synthaseGene clusterYeastGeneHeterologous expressionNaringeninBiologyATP synthaseChalconeGeneticsGene expressionBiochemistrySaccharomyces cerevisiaeChemistryFlavonoidStereochemistryRecombinant DNAAntioxidantPlant biochemistry and biosynthesisPlant Gene Expression AnalysisFungal Plant Pathogen Control