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Protective effects of Pyrogallol and Caffeic acid against Fe2+ -Ascorbate-induced oxidative stress in the wistar rats liver: An in vitro study

Seifollah Bahramikia, Nasrin Shirzadi, Vali Akbari

2025Heliyon11 citationsDOIOpen Access PDF

Abstract

values for DPPH free radicals for pyrogallol and caffeic acid were determined to be 76.26 μg/mL and 106.31 μg/mL, respectively. Notably, pyrogallol and caffeic acid exhibited higher antioxidant activity in all assays than catechin. In most assays (DPPH, Lipid peroxidation, and PCO) and at high concentrations (50 and 100 μg/mL), the antioxidative stress activity of pyrogallol was higher than that of caffeic acid. In conclusion, this study's results suggest that these compounds can potentially ameliorate diseases associated with oxidative stress.

Topics & Concepts

PyrogallolCaffeic acidOxidative stressIn vitroChemistryAntioxidantAscorbic acidBiochemistryPharmacologyTraditional medicineMedicineFood scienceVitamin C and Antioxidants ResearchMoringa oleifera research and applicationsNatural Antidiabetic Agents Studies
Protective effects of Pyrogallol and Caffeic acid against Fe2+ -Ascorbate-induced oxidative stress in the wistar rats liver: An in vitro study | Litcius