Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology
El Sayed H. El Ashry, Laila F. Awad, Mohamed Teleb, Nihal Ahmed Ibrahim, Marwa M. Abu‐Serie, Mohamed N. Abd Al Moaty
Topics & Concepts
PyrimidineChemistryMatrix metalloproteinaseStereochemistrySelectivityMatrix metalloproteinase inhibitorIC50Combinatorial chemistryIn vitroBiochemistryCatalysisProtease and Inhibitor MechanismsPeptidase Inhibition and AnalysisSignaling Pathways in Disease