Oxone-Promoted Synthesis of Bis(indolyl)methanes from Arylmethylamines and Indoles
Vikas D. Kadu, Amruta A. Patil, Prajakta R. Shendage
Abstract
An environmentally benign synthesis of 3,3’-bis(indolyl)methanes (BIMs) has been developed from arylmethylamines and indoles under aerobic condition in presence of oxone . The formation of BIMs using ethanol as a green reaction medium represents a good practical method for synthesis. The good tolerance was observed towards various functional groups for exploring substrate scope in presence of oxone and the synthesized BIMs afforded in excellent yields up to 94%.
Topics & Concepts
ChemistryIndole testOrganic chemistryCombinatorial chemistrySynthesis of Indole DerivativesChemical Synthesis and ReactionsMulticomponent Synthesis of Heterocycles