Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma
Mary Jane Lim-Fat, Kun Song, J. Bryan Iorgulescu, Brian M. Andersen, Deborah Forst, Justin T. Jordan, Elizabeth R. Gerstner, David A. Reardon, Patrick Y. Wen, Isabel Arrillaga‐Romany
Topics & Concepts
CDKN2AMedicineTrametinibDabrafenibInternal medicinePTENOncologyVemurafenibIDH1Retrospective cohort studyMEK inhibitorCancerMutationMAPK/ERK pathwayBiologyPI3K/AKT/mTOR pathwayMetastatic melanomaApoptosisCell biologyBiochemistryGeneKinaseGlioma Diagnosis and TreatmentMelanoma and MAPK PathwaysCutaneous Melanoma Detection and Management