Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes
Hengte Xing, ChuanCai Liang, Chenyu Wang, Xiongfeng Xu, Yong Hu, Bo Qiu
Topics & Concepts
AMPKMetforminProtein kinase AAMP-activated protein kinaseChemistryABCA1EndocrinologyInternal medicineChondrocyteCartilageCholesterolCell biologyKinasePharmacologyMedicineBiochemistryBiologyDiabetes mellitusIn vitroTransporterAnatomyGenePeroxisome Proliferator-Activated ReceptorsOsteoarthritis Treatment and MechanismsNatural product bioactivities and synthesis