Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response
Mouna Rahabi, Godefroy Jacquemin, Mélissa Prat, Étienne Meunier, Mohamad Alaeddine, Bénédicte Bertrand, Lise Lefèvre, Khaddouj Benmoussa, Philippe Batigne, Agnès Aubouy, Johan Auwerx, Sylvain Kirzin, Delphine Bonnet, Marie Danjoux, Bernard Pipy, Laurent Alric, Hélène Authier, Agnès Coste
Abstract
monocyte population enrichment in the blood and their recruitment to inflamed colon as precursors of inflammatory macrophages. Dectin-1 also promotes inflammasome-dependent interleukin-1β (IL-1β) secretion through leukotriene B4 production. Interestingly, colonic inflammation is associated with a concomitant overexpression of dectin-1/CCL2/LTA4H and downregulation of MR on macrophages from IBD patients. Thus, MR and dectin-1 on macrophages are important mucosal inflammatory regulators that contribute to the intestinal inflammation.