Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases
Tatiane S. Lima, Sharmila Mallya, Allen Jankeel, Ilhem Messaoudi, Melissa B. Lodoen
Abstract
Toxoplasma gondii is an obligate intracellular parasite that can cause life-threatening disease in immunocompromised individuals and in the developing fetus. Interestingly, T. gondii has evolved strategies to successfully manipulate the host immune system to establish a productive infection and evade host defense mechanisms.
Topics & Concepts
CaspaseApoptosisBlocking (statistics)Toxoplasma gondiiCell biologyCytosolProliferating cell nuclear antigenLife spanChemistryProgrammed cell deathBiologyImmunologyAntibodyBiochemistryEnzymeEvolutionary biologyStatisticsImmunohistochemistryMathematicsToxoplasma gondii Research StudiesNeutrophil, Myeloperoxidase and Oxidative MechanismsCytomegalovirus and herpesvirus research