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Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

Monica Cassandras, Chaoqun Wang, Jaymin J. Kathiriya, Tatsuya Tsukui, Peri Matatia, Michael A. Matthay, Paul J. Wolters, Ari B. Molofsky, Dean Sheppard, Harold A. Chapman, Tien Peng

2020Nature Cell Biology105 citationsDOIOpen Access PDF

Topics & Concepts

Progenitor cellCell biologyMesenchymal stem cellTransdifferentiationBiologyRespiratory epitheliumGLI1Stromal cellCellular differentiationMyofibroblastReprogrammingMetaplasiaStem cellEpitheliumCancer researchImmunologyHedgehogFibrosisPathologyMedicineSignal transductionCellGeneGeneticsBiochemistryNeonatal Respiratory Health ResearchTumors and Oncological CasesCongenital Diaphragmatic Hernia Studies
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung | Litcius