Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring
Ryutaro Kanada, Yoshiko Kagoshima, Masayoshi Asano, Takashi Suzuki, Takeshi Murata, Makoto Haruta, Mizuki Takahashi, Osamu Ubukata, Kazuyuki Hashimoto, K Obata, Kawori Kihara, Mutsumi Kuroha, Toshihiro Banjo, Noriko Togashi, Kazumi Sato, Yuka Yamamoto, Kanae Suzuki, Takeshi Isoyama, Yuichi Tominaga, Saito Higuchi, Hiroyuki Naito
Topics & Concepts
ChemistryHistone acetyltransferaseHistone AcetyltransferasesAcetyltransferaseHistoneCancer researchHigh-throughput screeningCell biologyMolecular biologyAcetylationBiochemistryBiologyGeneProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways