Synthesis of benzoquinone compounds by a microdroplet-accelerated retro-Diels–Alder reaction
Nishkant Malkoti, Yifan Meng, Richard N. Zare, Elumalai Gnanamani
Abstract
The retro-Diels–Alder reaction benzoquinone products were obtained in milliseconds using microdroplet chemistry. Notably, 2.6 mg of the blue scorpion venom compound were obtained in 60% isolated yield.
Topics & Concepts
Diels–Alder reactionBenzoquinoneChemistryOrganic chemistryCombinatorial chemistryCatalysisBioactive Compounds and Antitumor AgentsMarine Sponges and Natural ProductsOxidative Organic Chemistry Reactions