c-Met-targeted near-infrared fluorescent probe for real-time depiction and dissection of perineural invasion and lymph node metastasis lesions in pancreatic ductal adenocarcinoma xenograft models
Dan Li, Meilin Yang, Mingzhu Liang, Chaoming Mei, Yujing Lin, Fan Yang, Yitai Xiao, Yuechuan Chen, Fen Wang, Junjie Mao, Zhongzhen Su
Abstract
< 0.05). The signal-to-background ratio (TBR) of an orthotopic PDAC tumour was 3.38 ± 0.46, and imaging with SHRmAb-IR800 facilitated the resection of metastatic lesions with sensitivity and specificity values of 93.3% (56/60) and 87.1% (27/31), respectively. Furthermore, tiny PNI and LNM lesions in xenograft models were detected by NIRF imaging, with TBRs measuring 2.59 ± 0.19 and 2.88 ± 0.72, respectively. Therefore, the clinical translation of this probe might shed new light on NIRF-guided pancreatectomy and improve the surgical prognosis of PDAC patients.
Topics & Concepts
Perineural invasionMedicineImmunohistochemistryIn vivoPathologyMetastasisLymph nodeAdenocarcinomaCancer researchPancreatic ductal adenocarcinomaDissection (medical)Pancreatic cancerCancerInternal medicineRadiologyBiologyBiotechnologyPancreatic and Hepatic Oncology ResearchCancer Cells and MetastasisNeuroendocrine Tumor Research Advances