From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity
Mohamed H. El‐Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Ahmed A. Al‐Karmalawy, Ebtehal M. Husseiny, Mona S. El‐Zoghbi, Hamada S. Abulkhair
Topics & Concepts
ChemistryPCAFBioisostereCytotoxicityApoptosisIC50Cell cycleCancer cellIn silicoStereochemistryPharmacologyCancerIn vitroBiochemistryAcetylationBiologyChemical synthesisGeneticsGeneProtein Degradation and InhibitorsCancer Mechanisms and TherapyMultiple Myeloma Research and Treatments