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From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity

Mohamed H. El‐Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Ahmed A. Al‐Karmalawy, Ebtehal M. Husseiny, Mona S. El‐Zoghbi, Hamada S. Abulkhair

2021Bioorganic & Medicinal Chemistry67 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryPCAFBioisostereCytotoxicityApoptosisIC50Cell cycleCancer cellIn silicoStereochemistryPharmacologyCancerIn vitroBiochemistryAcetylationBiologyChemical synthesisGeneticsGeneProtein Degradation and InhibitorsCancer Mechanisms and TherapyMultiple Myeloma Research and Treatments
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity | Litcius