Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues
Chao Shang, Xinyu Zhuang, He Zhang, Yiquan Li, Yilong Zhu, Jing Lu, Chenchen Ge, Jianan Cong, Tingyu Li, Nan Li, Mingyao Tian, Ningyi Jin, Xiao Li
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic with limited therapeutics. Insights into the virus-host interactions contribute substantially. The novelty of this study is the use of a new animal model: mice xenografted with human lung tissues.
Topics & Concepts
AutophagyBiologyAutophagosomeGenetically modified mouseTransgenePneumoniaCell biologyLungATG5Vero cellVirologyViral replicationCancer researchLysosomeVirusImmunologyCoronavirusRespiratory systemProgrammed cell deathNecroptosisPorcine reproductive and respiratory syndrome virusAutophagy in Disease and TherapyHydrogen's biological and therapeutic effectsRNA Interference and Gene Delivery