Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement
Kayla N. Berry, Tom J. Brett
Abstract
and that α6 atypically extends from the VWA core. Finally, an analysis of TMEM16A structures suggests residues likely to mediate interaction with CLCA1 VWA.
Topics & Concepts
ChemistryCalciumBiophysicsChloride channelBiochemistryBiologyOrganic chemistryIon channel regulation and functionCardiac electrophysiology and arrhythmiasBlood disorders and treatments