Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA
Gui-Bin Liang, Jian-Hua Wei, Hong Jiang, Ri-Zhen Huang, Jing-Ting Qin, Huiling Wang, Heng‐Shan Wang, Ye Zhang
Topics & Concepts
ChemistryDownregulation and upregulationApoptosisDNA damageComet assayCell cycleMolecular biologyCell cycle checkpointIn vivoCyclin B1BiochemistryDNACyclin-dependent kinase 1BiologyBiotechnologyGeneCancer therapeutics and mechanismsSynthesis of Tetrazole DerivativesQuinazolinone synthesis and applications