Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome
Joanna W. Jachowicz, Mackenzie Strehle, Abhik K. Banerjee, Mario R. Blanco, Jasmine Thai, Mitchell Guttman
Topics & Concepts
XISTX-inactivationGene silencingBiologyX chromosomeLong non-coding RNAGeneticsRNAGeneDosage compensationRegulation of gene expressionChromosomeCell biologyComputational biologyCancer-related molecular mechanisms researchRNA Research and SplicingRNA and protein synthesis mechanisms