IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units
Bruno Martins Tomazini, Antônio Paulo Nassar, Thiago Lisboa, Luciano César Pontes Azevedo, Viviane Cordeiro Veiga, Daniela Ghidetti Mangas Catarino, Débora Vacaro Fogazzi, Beatriz Arns, Filipe Teixeira Piastrelli, Camila Dietrich, Karina Leal Negrelli, Isabella de Andrade Jesuíno, Luiz F. L. Reis, Renata Rodrigues de Mattos, Carla Cristina Gomes Pinheiro, Mariane Nascimento Luz, Clayse Carla da Silva Spadoni, Elisângela Emilene Moro, Flávia Regina Bueno, Camila Santana Justo Cintra Sampaio, Débora Patrício Silva, Franca Pellison Baldassare, Ana Cecilia Alcantara Silva, Thabata Veiga, Letícia Galvão Barbante, Marianne Lambauer, Viviane Bezerra Campos, Elton Santos, Renato Hideo Nakawaga Santos, Ligia Nasi Laranjeiras, Nanci Valeis, Eliana Vieira Santucci, Tamiris Abait Miranda, Ana Cristina Lagoeiro do Patrocínio, Andréa de Carvalho, Eduvirgens Maria Couto de Sousa, Ancelmo Honorato Ferraz de Sousa, Daniel Tavares Malheiro, Isabella Lott Bezerra, Mirian Batista Rodrigues, Julliana Chicuta Malicia, Sabrina Souza da Silva, Bruna dos Passos Gimenes, Guilhermo Prates Sesin, Alexandre Prehn Zavascki, Daniel Sganzerla, Gregory Saraiva Medeiros, Rosa da Rosa Minho dos Santos, Fernanda Kelly Romeiro Silva, Maysa Yukari Cheno, Carolinne Ferreira Abrahão, Haliton Alves de Oliveira, Leonardo Lima Rocha, P A Nunes Neto, Valéria Chagas Pereira, Luís Eduardo Miranda Paciência, Elaine Silva Bueno, Eliana Bernadete Caser, Larissa Zuqui Ribeiro, Caio César Ferreira Fernandes, Juliana Mazzei Garcia, Vanildes de Fátima Fernandes Silva, Alisson Júnior dos Santos, Flávia Ribeiro Machado, Maria Aparecida de Souza, Bianca Ramos Ferronato, Hugo Corrêa de Andrade Urbano, Danielle C. A. Moreira, Vicente Cés de Souza-Dantas, Diego Meireles Duarte, Juliana Coelho, Rodrigo C. Figueiredo, Fernanda Foreque, Thiago Gomes Romano, Daniel Caraca Cubos, Vladimir Miguel Spirale, Roberta Schiavon Nogueira, Israel Silva Maia, Cássio Luis Zandonai, Wilson José Lovato, Rodrigo Barbosa Cerantola, Tatiana Gozzi Pancev Toledo, Pablo Oscar Tomba, Joyce Ramos de Almeida, Luciana Coelho Sanches, Leticia Pierini, Mariana Sequetin Cunha, Michelle Tereza Sousa, Bruna Marcacini Azevedo, Felipe Dal‐Pizzol, Danusa Damásio, Marina Peres Bainy, Dagoberta Alves Vieira Beduhn, Joana D’Arc Vila Nova Jatobá, Maria Tereza Farias de Moura, Leila Rezegue de Moraes Rego, Adria Vanessa da Silva, Luana Pontes Oliveira, Eliene Sá Sodré Filho, Silvana Soares dos Santos
Abstract
OBJECTIVE: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. METHODS: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. RESULTS: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. CONCLUSION: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials.