Litcius/Paper detail

When Silence Disrupts

Ryan Hunt, Chava Kimchi‐Sarfaty

2022New England Journal of Medicine46 citationsDOI

Abstract

Genomes have different types of genetic variation, and many changes are assumed to be “silent” — that is, they have no effect on biology, health, or fitness. A recent study shows that it is not that simple.

Topics & Concepts

SilenceVariation (astronomy)GenomeEvolutionary biologyGenetic variationMedicineSimple (philosophy)GeneticsBiologyGeneEpistemologyAestheticsPhysicsAstrophysicsPhilosophyGenomics and Rare DiseasesEvolution and Genetic DynamicsCRISPR and Genetic Engineering