Uptake of collagen type I via macropinocytosis cause mTOR activation and anti-cancer drug resistance
Shota Yamazaki, Yinghan Su, Ami Maruyama, Hideki Makinoshima, Jun Suzuki, Masahiro Tsuboi, Kōichi Goto, Atsushi Ochiai, Genichiro Ishii
Topics & Concepts
Tyrosine-kinase inhibitorCancer researchPI3K/AKT/mTOR pathwayProtein kinase BCancer cellPinocytosisEpidermal growth factor receptorChemistryGefitinibFlow cytometryEndocytosisBiologyCancerCell biologyMolecular biologyCellReceptorSignal transductionBiochemistryGeneticsPI3K/AKT/mTOR signaling in cancerInflammatory mediators and NSAID effectsCell Adhesion Molecules Research