Quercetin potentiates the hepatoprotective effect of sildenafil and/or pentoxifylline against intrahepatic cholestasis: Role of Nrf2/ARE, TLR4/NF-κB, and NLRP3/IL-1β signaling pathways
Michael Atef Fawzy, Gehad Nasr, Fares E.M. Ali, Moustafa Fathy
Topics & Concepts
CholestasisPharmacologySildenafilLiver injuryChemistrycGMP-specific phosphodiesterase type 5TLR4Oxidative stressPentoxifyllineBilirubinTadalafilPhosphodiesteraseAntioxidantMedicineSignal transductionInternal medicineBiochemistryEnzymeLiver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms