Bioactive phytoconstituents as potent inhibitors of casein kinase-2: dual implications in cancer and COVID-19 therapeutics
Farah Anjum, Md Nayab Sulaimani, Alaa Shafie, Taj Mohammad, Ghulam Md Ashraf, Anwar L. Bilgrami, Fahad A. Alhumaydhi, Suliman A. Alsagaby, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Abstract
Showing protein–ligands interactions, electrostatic potential of CK2 bound to selected compounds, free energy landscapes of CK2-stylopine, and CK2-dehydroevodiamines complexes.
Topics & Concepts
Casein kinase 2Lipinski's rule of fiveVirtual screeningComputational biologyKinaseIn vitroChemistryIn vivoThreonineHeLaBiochemistrySerineProtein kinase ABiologyDrug discoveryPhosphorylationIn silicoCyclin-dependent kinase 2GeneBiotechnologyBiochemical and Structural CharacterizationPhytochemical compounds biological activitiesMicrobial Natural Products and Biosynthesis