Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies
Emanuele Monda, Giuseppe Palmiero, Marta Rubino, Federica Verrillo, Federica Amodio, Francesco Di Fraia, Roberta Pacileo, Fabio Fimiani, Augusto Esposito, Annapaola Cirillo, Adelaide Fusco, Elisabetta Moscarella, Giulia Frisso, Maria Giovanna Russo, Giuseppe Pacileo, Paolo Calabrò, Olga Scudiero, Martina Caiazza, Giuseppe Limongelli
Abstract
Cardiomyopathies (CMPs) represent a diverse group of heart muscle diseases, grouped into specific morphological and functional phenotypes. CMPs are associated with mutations in sarcomeric and non-sarcomeric genes, with several suspected epigenetic and environmental mechanisms involved in determining penetrance and expressivity. The understanding of the underlying molecular mechanisms of myocardial diseases is fundamental to achieving a proper management and treatment of these disorders. Among these, inflammation seems to play an important role in the pathogenesis of CMPs. The aim of the present study is to review the current knowledge on the role of inflammation and the immune system activation in the pathogenesis of CMPs and to identify potential molecular targets for a tailored anti-inflammatory treatment.