Alternol triggers immunogenic cell death <i>via</i> reactive oxygen species generation
Changlin Li, Ying Zhang, Siyuan Yan, Guoan Zhang, Wei Wei, Zhi Qi, Benyi Li
Abstract
, resulting in delayed tumor growth and prolonged survival. Moreover, inhibition of reactive oxygen species (ROS) generation blocked Alternol-induced upregulation of pre-inflammation cytokines, endoplasmic reticulum (ER) stress, and consequent antitumor immune response. Overall, our data indicate that Alternol triggers ICD in prostate cancer cells, which is mediated by ROS generation.
Topics & Concepts
Immunogenic cell deathCalreticulinCancer researchImmune systemHMGB1CytokineProstate cancerImmunologyInflammationT cellMedicineCancerBiologyImmunotherapyEndoplasmic reticulumCell biologyInternal medicineCancer Immunotherapy and BiomarkersAtherosclerosis and Cardiovascular DiseasesT-cell and B-cell Immunology