Oral radiation‐induced sarcomas: Systematic review
Lucas Lacerda de Souza, Hélder Antônio Rebelo Pontes, Alan Roger Santos‐Silva, Lais Albuquerque FERNANDES, Luana Araújo Lobo Batista, Márcio Ajudarte Lopes, Waqas Ullah Khan, Flávia Sirotheau Corrêa Pontes
Abstract
BACKGROUND: The aim of this study was to integrate the available data published on radiation-induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. METHODS: An electronic search was undertaken in September 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. RESULTS: Forty-two publications with 122 radiation-induced sarcoma of the oral cavities (RISOCs) were included. The mean latency period was 114 months and mean radiation total dose was 62.5 Gy. The tumors were more prevalent in males between 50 and 60 years old and the mandible was the most affected site. Osteosarcoma was the most prevalent histological type and patients were mostly treated with radical surgery. CONCLUSIONS: RISOC showed a poor survival rate of 15.1% in 5-year follow-up. Gender and histological type were independently associated with survival.