METTL3-mediated m6A modification of OTUD1 aggravates press overload induced myocardial hypertrophy by deubiquitinating PGAM5
Kai Huang, Xiaotian Sun, Xiangyang Xu, Jie Lu, Boyao Zhang, Li Qin, Chuyi Wang, Sufan Ding, Xiaolei Huang, Xiaohong Liu, Zhiyun Xu, Lin Han
Abstract
: Our findings confirm that targeting the OTUD1-PGAM5 axis holds significant potential as a therapeutic approach for heart failure associated with pathological hypertrophy.
Topics & Concepts
Deubiquitinating enzymeCardiologyUbiquitinInternal medicineMyocardial hypertrophyMuscle hypertrophyMedicineCell biologyChemistryBiologyBiochemistryGeneRNA modifications and cancerPeptidase Inhibition and AnalysisGalectins and Cancer Biology