Copper-catalyzed enantioselective alkene carboetherification for the synthesis of saturated six-membered cyclic ethers
Ilyas A. Berhane, Ameya S. Burde, Jonathan J. Kennedy-Ellis, Eva Zurek, Sherry R. Chemler
Abstract
receptor ligand using this alkene carboetherification methodology was demonstrated. Ligand, solvent and base all impact reaction efficiency. DFT transition state calculations are presented.
Topics & Concepts
Enantioselective synthesisAlkeneCatalysisLigand (biochemistry)ChemistryCopperSolventFormal synthesisOrganic chemistryCombinatorial chemistryMedicinal chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality Synthesis