Alcohol promoted <i>N</i>-methylation of anilines with CO<sub>2</sub>/H<sub>2</sub> over a cobalt catalyst under mild conditions
Zhengang Ke, Yanfei Zhao, Ruipeng Li, Huan Wang, Wei Zeng, Minhao Tang, Buxing Han, Zhimin Liu
Abstract
Alcohol shifts the equilibrium of CO 2 hydrogenation via forming alkyl formate, which further reacts with amine to produce N -formamide, and Sn(OTf) 2 promotes hydrogenation of N -formamide to N -methylamine.
Topics & Concepts
MethylamineFormamideCatalysisCobaltFormateChemistryAlcoholMedicinal chemistryAmine gas treatingAlkylOrganic chemistryCarbon dioxide utilization in catalysisCO2 Reduction Techniques and CatalystsAsymmetric Hydrogenation and Catalysis