A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors
Christopher R. McEvoy, Holly Holliday, Niko Thio, Catherine Mitchell, David Choong, Bhargavi Yellapu, Hui San Leong, Huiling Xu, Stephen Lade, Judy Browning, Elena A. Takano, David J. Byrne, Anthony J. Gill, Cuong P. Duong, Jason Li, Andrew Fellowes, Stephen B. Fox, Alexander Swarbrick, Owen W.J. Prall
Topics & Concepts
BiologyCancer researchHRASFusion geneTranscriptomeCarcinogenesisOncogene ProteinsGeneFusion proteinRepressorBMI1GeneticsTranscription factorRegulation of gene expressionGene expressionMutationKRASRecombinant DNAProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments