Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin—A Human Experimental Study
Emelie Rietz Liljedahl, Gunnar Johanson, Helena Korres de Paula, Moosa Faniband, Eva Assarsson, Margareta Littorin, Malin Engfeldt, Carola Lidén, Anneli Julander, Karin Wahlberg, Christian Lindh, Karin Bröberg
Abstract
BACKGROUND: may increase dermal absorption of chemicals. OBJECTIVE: genotype. METHOD: repeat copy number variants (CNV), and we performed population toxicokinetic analysis. RESULTS: ) for pyrimethanil than wt carriers with low and high CNV, respectively. CONCLUSION: CNV resulted in increased dermal absorption of chemicals. https://doi.org/10.1289/EHP7310.
Topics & Concepts
FilaggrinChemistryPopulationPyrimethanilBiochemistryBiologyImmunologyPesticideMedicineEcologyEnvironmental healthAtopic dermatitisDermatology and Skin DiseasesComplementary and Alternative Medicine StudiesAllergic Rhinitis and Sensitization