Macrophage activation syndrome in systemic juvenile idiopathic arthritis
Masaki Shimizu
Abstract
exposure to highly elevated levels of IL-6 and IL-18 might induce natural killer cell dysfunction and decrease their numbers, respectively. A proper diagnosis is important to begin appropriate therapeutic interventions and change an unfavorable prognosis. The 2016 ACR/EULAR classification criteria for MAS have a high diagnostic performance; however, the diagnostic sensitivity for onset is relatively low. Therefore, careful monitoring of laboratory values during the course of MAS is necessary to diagnose it early in s-JIA. Further studies on the diagnosis and monitoring of disease activity using serum cytokine profile and a targeted cytokine strategy are required.
Topics & Concepts
Macrophage activation syndromeMedicineImmunologyHemophagocytic lymphohistiocytosisCytokineTumor necrosis factor alphaArthritisPathogenesisMacrophageDiseaseInternal medicineBiologyIn vitroBiochemistryAutoimmune and Inflammatory Disorders ResearchAdolescent and Pediatric HealthcareImmune Cell Function and Interaction