Rhodium-catalyzed formal four-component reaction with hypervalent iodine diazoesters, alcohols, and isatins for the synthesis of multi-functionalized oxindoles
Jie Tang, Xiaoyan Yang, Gejun Niu, Tianyuan Zhang, Wenhao Hu, Yu Qian
Abstract
A novel Rh( ii )-catalyzed formal four-component reaction involving hypervalent iodine diazoesters, alcohols, and isatins was effectively established as an efficient process to produce multi-functionalized oxindoles in good to high yields.
Topics & Concepts
Hypervalent moleculeChemistryIodineRhodiumCatalysisCombinatorial chemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions