KCNQ3 is the principal target of retigabine in CA1 and subicular excitatory neurons
Nissi Varghese, Anna Lauritano, Maurizio Taglialatela, Anastasios V. Tzingounis
Abstract
Retigabine has risen to prominence as a first-in-class potassium channel opener approved by the Food and Drug Administration, with potential for treating multiple neurological disorders. Here, we demonstrate that KCNQ3 channels are the primary target of retigabine in excitatory neurons, as deleting these channels greatly diminishes the effect of retigabine in pyramidal neurons. Our data provide the first indication that retigabine controls neuronal firing properties primarily through KCNQ3 channels.
Topics & Concepts
NeurosciencePotassium channelExcitatory postsynaptic potentialSubiculumPharmacologyChemistryHippocampusInhibitory postsynaptic potentialMedicinePsychologyInternal medicineDentate gyrusIon channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research