Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
Robyn Borsuk, Lanlan Zhou, Wen-I Chang, Yiqun Zhang, Aditi Sharma, Varun V. Prabhu, Nikos Tapinos, Rishi Lulla, Wafik S. El‐Deiry
Abstract
and in clinical trials.
Topics & Concepts
PanobinostatRomidepsinMedicineCancer researchEtoposideGliomaPharmacologyInternal medicineHistone deacetylaseBiologyHistoneChemotherapyBiochemistryGeneGlioma Diagnosis and TreatmentHistone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors