Electrochemically enabled cobalt catalyzed enantioselective C–H acyloxylation of aryl phosphamide with carboxylic acid
Xuying Xia, Changdi Zheng, Yunfei Hang, Jiyuan Guo, Tao Liu, Dingguo Song, Zhiwei Chen, Weihui Zhong, Fei Ling
Abstract
We described here the first example of cobalt-electro-catalyzed enantioselective C–H acyloxylation of arylphosphinamides with carboxylic acids to generate P-stereogenic scaffolds.
Topics & Concepts
Enantioselective synthesisCatalysisChemistryCobaltCarboxylic acidElectrochemistryArylOrganic chemistryCombinatorial chemistryElectrodePhysical chemistryAlkylAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Reactions and Isotopes