L-carnitine protects DNA oxidative damage induced by phenylalanine and its keto acid derivatives in neural cells: a possible pathomechanism and adjuvant therapy for brain injury in phenylketonuria
Jéssica Lamberty Faverzani, Aline Steinmetz, Marion Deon, Desirèe Padilha Marchetti, Gilian Guerreiro, Ângela Sitta, Daniella de Moura Coelho, Franciele Fátima Lopes, Leopoldo Vinicius Martins Nascimento, Luiza Steffens Reinhardt, Jeferson Gustavo Henn, Matheus Bernardes Ferro, Verônica Bidinotto Brito, Moaçir Wajner, Dinara Jaqueline Moura, Carmen Regla Vargas
Topics & Concepts
Oxidative stressPhenylalanineChemistryReactive oxygen speciesDNA damageIn vivoPhenylpyruvic acidCarnitineViability assayPharmacologyBiochemistryAntioxidantLipid peroxidationBrain damageAmino acidIn vitroInternal medicineMedicineBiologyDNABiotechnologyMetabolism and Genetic DisordersMetabolomics and Mass Spectrometry StudiesMitochondrial Function and Pathology