Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site
Ibrahim H. Eissa, Mohammed A. Dahab, Mohamed K. Ibrahim, Nawaf A. Alsaif, Ahmed Z. Alanazi, Sally I. Eissa, Ahmed B. M. Mehany, André M. Beauchemin
Topics & Concepts
ChemistryTubulinColchicineCytotoxicityCombretastatinMicrotubule polymerizationCell cycle checkpointMicrotubuleCell cycleIn vitroApoptosisStereochemistryCell cultureIC50BiochemistryCell biologyBiologyGeneticsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis and Biological Evaluation